| Filmography |
| Bee Movie | Queen Bee (voice) | 2007 |
| Rebound | Principal Walsh | 2005 |
| Teacher's Pet | Adele (voice) | 2004 |
| The Pact | Melanie Gold | 2002 |
| Stealing Harvard | Patty Plummer | 2002 |
| Monkeybone | Kimmy Miley | 2001 |
| Speaking of Sex | Jennifer Klink | 2001 |
| Everything Put Together | Barbie | 2000 |
| Best Man In Grass Creek | Co-Worker | 1999 |
| Anywhere But Here | Woman Buying Car | 1999 |
| Winchell | June Winchell | 1998 |
| Couples | 1994 | |
| I Yabba-Dabba Doo | Pebbles Flintstone | 1993 |
| Queen’s Logic | Dolores | 1991 |
| Rainbow Drive | Ava Zieff | 1990 |
| About Last Night... | Pat | 1986 |
| Last Resort | Jessica Lollar | 1986 |
| Under the Biltmore Clock | Lilah | 1986 |
| Once Bitten | Suzette | 1985 |
| First Steps | Cathy | 1985 |
| Risky Business | Call Girl | 1983 |
| The Children Nobody Wanted | Sharon | 1981 |
TV Series
| The Megan Mullally Show | Herself (Host) | 2006-2007 |
| Will and Grace | Karen Walker | 1998-2006 |
| Rachel Gunn, R.N. | Becky Jo | 1992 |
| Fish Police | Pearl (voice) | 1992 |
| My Life and Times | Susan | 1991 |
| The Ellen Burstyn Show | Molly Brewer Ross | 1986 |
TV Guest Appearances
| Boston Legal Episode: The Bride Wore Blood | Renata Hill/Sarah Popeil | 2007 |
| Peep and the Big Wide World Episode: Quack Quack/One Quack Too Many | Pink Quack (voice) | 2006 |
| How I Met Your Mother Episode 2.10: Single Stamina | Barney’s mother (voice) | 2006 |
| King of the Hill Episode 6.16: Beer and Loathing | Teresa (voice) | 2002 |
| 3rd Rock from the Sun Episode 6.01: Les Liaisons Dickgereuses | Renata Albright | 2000 |
| Just Shoot Me! Episode 2.21: Amblushed | Stephanie Griffin-Cooper | 1998 |
| Caroline in the City Episode 3.12: Caroline and the Decanter | Vanessa | 1997 |
| The Naked Truth Episode 3.09: He Ain’t Famous, He’s My Brother | Vanessa | 1997 |
| Extreme Ghostbusters Episode 1.03: True Face of a Monster | (voice) | 1997 |
| Mad About You Episode 5.21: Guardianhood | Jane | 1997 |
| Frasier Episode 4.13: Four for the Seesaw | Beth Armstrong | 1997 |
| Ned and Stacey Episode 2.11: Where My Third Nepal Is Sheriff | Wendy | 1997 |
| Batman Episode 2.06: House and Garden | Cindy (voice) | |
| Seinfeld Episode 4.19: The Implant | Betsy | 1993 |
| Herman’s Head Episode 2.23: I Wanna Go Home Episode 1.05: Fatal Distraction | Yvonne | 1991 |
| Wings Episode 1.05: There Once Was a Girl From Nantucket | Cindy | 1990 |
| China Beach Episode 2.17: The World – Part 2 | Cindy | 1989 |
| Murder, She Wrote Episode 5.05: Coal Miner’s Slaughter | Molly Connors | 1988 |